# What are the potential side effects of taking Celebrex for arthritis?

Paige Thornton · August 4, 2026

> Celebrex can increase the risk of heart attack and stroke, especially in those with pre-existing cardiovascular disease. This risk appears to be higher...

Celebrex can increase the risk of heart attack and stroke, especially in those with pre-existing cardiovascular disease.

This risk appears to be higher with long-term use.

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Celebrex may cause serious gastrointestinal side effects like stomach ulcers, bleeding, and perforation, particularly in the elderly or those with a history of ulcers.

Celebrex has been associated with an increased risk of serious skin reactions like Stevens-Johnson syndrome and toxic epidermal necrolysis, which can be life-threatening.

Celebrex may interfere with the anti-platelet effects of low-dose aspirin, potentially reducing its cardiovascular protective benefits.

Patients with advanced kidney disease may be at higher risk of kidney dysfunction when taking Celebrex.

Celebrex can cause fluid retention and edema, which may exacerbate heart failure in susceptible individuals.

Celebrex has been linked to an increased risk of atrial fibrillation, a type of abnormal heart rhythm.

Celebrex may interact with certain antidepressants (SSRIs) and anticoagulants, potentially increasing the risk of bleeding.

Celebrex can cause reversible infertility in women by delaying or preventing ovulation.

Celebrex has been associated with a higher risk of diverticulitis, a painful inflammation of the intestines.

Celebrex may worsen asthma symptoms in some patients, particularly those with aspirin-sensitive asthma.

Long-term use of Celebrex has been linked to an increased risk of hypertension and worsening of pre-existing high blood pressure.

Celebrex may increase the risk of bone fractures, especially in the elderly and those with osteoporosis.

Celebrex has been shown to impair liver function, particularly in those with pre-existing liver disease.

Celebrex can cause dizziness, drowsiness, and blurred vision, which may impact a patient's ability to drive or operate machinery.

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